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  • EphB and ephrinB mRNA levels were determined from three part

    2019-07-11

    EphB4 and ephrinB2 mRNA levels were determined from three parts taken from each tumor, and each sample was analyzed in triplicate. The differences in the histoscores and mRNA levels of EphB4 and ephrinB2 were analyzed by Student\'s t test. The correlation coefficients were evaluated both by linear regression analysis and bivariate Pearson correlation. Survival rates were calculated using the Kaplan–Meier method and analyzed by the log-rank test. Differences were considered significant when p was less than 0.05.
    Results Immunohistochemical staining for EphB4 and ephrinB2 of a representative case of squamous cell carcinoma of uterine cervix is shown in Fig. 1. All of the uterine cervical cancer specimens revealed strong staining for EphB4 and ephrinB2 in the cancer Fidaxomicin weight and very faint staining in vascular endothelial cells. Both EphB4 and ephrinB2 histoscores in cancer cells and mRNA levels in uterine cervical cancers significantly increased according to clinical stage (I Discussion In the present study, coexpression of EphB4 and ephrinB2 revealed a significant positive correlation of clinical stage, tumor size, and lymph node metastasis with poor patient prognosis. Overexpression of EphB4 and ephrinB2 in tumor cells indicates that EphB/ephrinB signaling drives interactions among the tumor cells, which may result in destabilization and affect cell–matrix attachment leading to promotion of invasion and metastasis [20].